Symptoms improved from week 3 of taking VEOZA.
Patient has improved quality of life.

Patient is satisfied with quality of life using VEOZA and vaginal oestrogen.

“She was otherwise fit and healthy with a BMI of 24 and following a healthy diet and practising weight bearing exercises on a regular basis. She had been to her GP who had prescribed her vaginal oestrogen pessaries for genitourinary symptoms and offered an SSRI* (medication) for vasomotor symptoms and low mood. The GP had referred her to a specialist menopause clinic for advice about transdermal HRT. She started using vaginal oestrogen with good benefit however didn’t start the SSRI* as she felt she wasn’t depressed.

In the specialist menopause clinic, there was discussion about non-HRT as well as hormonal treatments for hot flushes, night sweats and sleep disturbance. Although evidence about long-term safety of transdermal HRT is minimal related to specific conditions like factor V Leiden, clinical experience suggests that transdermal HRT can be a treatment option for her.

She was not willing to try systemic HRT due to concerns about thrombosis/stroke and decided to opt for an alternative non-hormonal therapy; fezolinetant. She started taking an oral 45mg VEOZA tablet daily. At follow up her hot flushes, night sweats and sleep improved from the third week of taking fezolinetant and she was satisfied with her current quality of life; combining fezolinetant and vaginal oestrogen. She had not noticed any side effects.